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That gave encouragement to others that rigorous experimental work addressing brain-behavior relations was possible in infants. It also fundamentally altered the scientific understanding of PFC early in development; clearly it was not silent as accepted wisdom had held.
Even though PFC is very immature early in life and takes a very long time to develop, it can already subserve elementary versions of the highest cognitive functions during the first year of life.
Diamond went on to facilitate many of the earliest collaborations between developmental and cognitive scientists, on the one hand, and neuroscientists on the other.
She provided the first demonstration of a visual deficit in treated PKU children which changed international guidelines for the age of treatment onset. No one had ever done anything like that. Again, the answer lay in integrating two fields.
Neuropharmacologists studying the mesocortical dopamine system in rats had shown that if there is only a modest reduction in the dopamine precursor, tyrosine, PFC is selectively affected.
To test that hypothesis, Diamond again turned to work in both humans and animals. They were thereby able to demonstrate the mechanism causing the deficits that had so confounded those working in inborn errors of metabolism, and to demonstrate that the deficits could be prevented by stricter dietary restrictons.
Midway through, Diamond learned that the dopamine system in the retina shares the same unusual properties as those that cause PFC to be sensitive to reductions in available tyrosine too small to affect other brain regions. To be consistent, she had to predict that retinal function would also be adversely impacted in children treated for PKU, so she ventured into vision science to investigate that together with pediatric optometrist, Dr.
Two superficially unrelated behavioral effects a selective cognitive deficit and a selective visual deficit were found to have same underlying cause. An animal model of early-treated PKU.
Journal of Neuroscience, 14, Diamond, A. Impaired sensitivity to visual contrast in children treated early and continuously for PKU. Prefrontal cortex cognitive deficits in children treated early and continuously for PKU.
Cognitive deficits in a genetic mouse model of the most common biochemical cause of human mental retardation. Journal of Neuroscience, 19, A model system for studying the role of dopamine in prefrontal cortex during early development in humans.
Reprinted in Reader in brain development and cognition. One discrepancy troubled Diamond, however. The visual deficits were not. By the time her team studied contrast sensitivity, they knew what range of Phe levels produced a deficit and so only sampled from within that range.
Having a truncated range of current Phe levels could easily have accounted for the failure to find a relation between contrast sensitivity and current Phe levels. However, a child born with PKU is usually not started on treatment for the disorder until about 10 days of age.
The visual system is maturing very rapidly during the days and weeks right after birth. Perhaps the excessively high levels of Phe reaching the brain during those first days after birth impairs the visual system.
To test that hypothesis Diamond brought in pairs of siblings, both of whom had PKU, as well as children from the general population. The importance of the sibling pairs was that while PKU in the first child born with the disorder is not detected until the heel prick test after birth, amniocentesis is performed for all later-born children and so it is known if any of those children have PKU before birth.
The first-born children started dietary treatment on average at 11 days of age, while the later-born children started the diet on average at 3 days of age. They found consistently that the first PKU sibling in a family had poorer contrast sensitivity at low levels of contrast than his or her younger PKU sibling and than children from the general population.
The children whose brains were exposed to massive levels of Phe for the first 10 days of life showed no deficits in visual acuity or in determining form from texture, but they were impaired in contrast sensitivity at very low levels of contrast and in determining form from motion.Writing services address one of the top challenges in content marketing: creating enough quality, original content to satisfy and engage an audience.
Postgraduate and masters degree information for international and EU students wishing to study in the UK. Where to apply, how to apply and entry requirements. About Us Resilient Cities—Pioneered by The Rockefeller Foundation (RC) is dedicated to helping cities around the world become more resilient to the physical, social and economic challenges that are a growing part of the 21st century.
Call +91 Pune PhD & Masters Thesis & Dissertation writing and editing services. Premium quality, prompt delivery. Full time writers, no freelancers. Data safe & confidential. Last week I went on a rare expenses paid jolly to Germany. I was guest of Bavarian housebuilder Baufritz who, like many others in Germany, have watched Huf Haus blaze a trail into the UK selfbuild market and would like to do the same themselves.
There are something like a hundred fertighaus (factory house) companies in Germany, in the Huf Haus/Baufritz mould.
Abhiyan Humane (On leave) Abhiyan Humane is an artist and scholar interested in perception, manifestation, and interpretation of information.
He experiments with light, photosensitivity, and motion.